Protein–Protein Communication Mediated by an Antibody‐Responsive DNA Nanodevice**

Abstract We report here the rational design and optimization of an antibody‐responsive, DNA‐based device that enables communication between pairs of otherwise non‐interacting proteins. The device is designed to recognize and bind a specific antibody and, in response, undergo a conformational change that leads to the release of a DNA strand, termed the “translator,” that regulates the activity of a downstream target protein. As proof of principle, we demonstrate antibody‐induced control of the proteins thrombin and Taq DNA polymerase. The resulting strategy is versatile and, in principle, can be easily adapted to control protein–protein communication in artificial regulatory networks.