CD64
受体
CD16
碎片结晶区
免疫球蛋白Fc片段
新生儿Fc受体
细胞生物学
免疫球蛋白G
化学
结合位点
免疫学
生物物理学
抗体
分子生物学
生物
生物化学
抗原
CD8型
CD3型
作者
Anu Tamm,Reinhold Schmidt
标识
DOI:10.3109/08830189709045703
摘要
The structure for the three human Fc gamma receptors classes Fc gamma RI (CD64), Fc gamma RII (CD32) and Fc gamma RIII (CD16) has been well characterized. Here the IgG binding sites on Fc gamma RII and Fc gamma RII with their responsive FG, BC and C'/E loops on the membrane proximal domains are described in detail. For Fc gamma RI the second extracellular domain is suggested as a key structure of IgG binding. The lower hinge regions of human and murine IgG binding to these Fc receptors and their structural relationship in Fc gamma R-IgG interactions are discussed. The potential of inhibiting the pathophysiological effects of Fc gamma receptors by blocking studies are considered for future therapeutic modalities.
科研通智能强力驱动
Strongly Powered by AbleSci AI