Synthesis of Aryl Trifluoromethyl Ketones

Trifluoromethyl ketones have recently been attracting considerable attention because they represent powerful synthetic building blocks with potential pharmaceutical applications. This short review provides an overview of recent development in the synthesis of aryl trifluoromethyl ketones with novel reagents. 1 Introduction 2 Various Methods for the Synthesis of Aryl Trifluoromethyl Ketones­ 2.1 Oxidation of Trifluoromethyl Alcohols 2.2 Nucleophilic Trifluoromethylation Reactions 2.3 Electrophilic-Type Reactions 2.4 Recently Developed Direct Trifluoroacetylation 3 Conclusions