泡沫电池
脂质积聚
细胞内
细胞
化学
脂蛋白
动脉壁
细胞生物学
胆固醇
医学
生物化学
生物
内科学
出处
期刊:Current Opinion in Lipidology
[Ovid Technologies (Wolters Kluwer)]
日期:2018-08-01
卷期号:29 (4): 279-284
被引量:35
标识
DOI:10.1097/mol.0000000000000525
摘要
Lipoprotein-induced intracellular lipid accumulation (foam cell formation) is a trigger of atherogenesis at the subendothelial arterial cell level. The purpose of this review is to describe the recent data related to the possible mechanisms of LDL-induced formation of lipid-laden foam cells and their role in the onset and development of atherosclerotic lesion.The most interesting current studies are related to the factors affecting foam cell formation.The phenomenon of lipid accumulation in cultured cells became the basis for creating a cellular test system that has already been successfully applied for development of drugs possessing direct antiatherosclerotic activity, and then the efficacy of these drugs was demonstrated in clinical studies. Moreover, this test system could be used for diagnostic assessing lipoproteins atherogenicity.
科研通智能强力驱动
Strongly Powered by AbleSci AI