the Synthesis Process of Glufosinate-ammonium and its Intermediate

The chief aim is to investigate the preparation process of glufosinate-ammonium by non-Strecker reaction,without using highly toxic cyanide as reactant.[Methods] Diethyl chlorophosphite was prepared from cheap and easily available phosphorous trichloride and triethyl phosphite,and then DEMP was synthesized by Grignard reaction.Ethyl methyl 2-bromide phosphate was produced under the self-made catalyst by the reaction of DEMP and dibromoethane.The obtained bromide was reacted with diethyl acetamidomalonate anion in toluene followed by acidification with hydrochloric acid and ammonification with ammonia to afford glufosinate-ammonium.[Results] The yield of DEMP was 57.6% based on phosphorous trichloride and that of glufosinate-ammonium was 25.8% based on DEMP.The properties of the product are consistent with the literature.[Conclusions] The preparation process in this paper has some advantages of low cost,relatively high yield and easy for industrialization.The process yield of ethyl methyl 2-bromide phosphate may be enhanced by optimizing the catalyst used in the reaction of DEMP with Dibromoethane.The yield of glufosinate-ammonium synthesized by method mentioned in this paper is slightly lower than that by Strecker method using cyanide.