Objective:To explore etiological and related risk factors of pathological jaundice of newborn and evaluate the effects on the bilirubin encephalopathy in early stage.Methods:The pathogeny factors of 183 cases newborn pathological jaundices were analyzed retrospectively.Results:The pathogeny of newborn pathological jaundices was as follows: infection 90(49.4%),perinatal period factors(16.4%),breast milk jaundice(15.8%),unknown causes(10.2%),hemolytic disease(4.4%),and inborn disease(3.8%).Patients were put into treatment of Blue light exposure combined with relevant measure.Conclusions:It can decrease the occurrence of pathological care,provide correct guidance in breast milk feeding and decreasing rate of caesarean birth.The pathological jaundice of newborn could be well prevented by a series of treatments in duration of pregnancy.