Objective To reduce the intravenous admixture defects and ensure the safety of clinical medication. Methods The quality management team of intravenous admixture was established,the intravenous admixture defects from January to June in 2012 were analyzed,and the improvement strategies was implemented and checked circularly. Results The rate of intravenous admixture defects dropped from 0. 040 9% to 0. 005 4% with an extremely significant difference( P 0. 01). Conclusion It can provide the safety for clinical medicine by establishing the quality management team to sustain the improvement about the quality and reduce defects effectively in various stage of intravenous drugs configuration.