Treatment of Metabolic Syndrome with Puerarin in Rats

OBJECTIVE To observe the effects of puerarin on metabolic syndrome(MS).METHODS The Wistar rats were fed with 10% fructose water.Fasting blood glucose,insulin,TG were determined and the insulin sensitivity index(ISI) was calculated after 6 weeks.The rats were intravascully given puerarin high dose(100 mg·kg-1)and puerarin low dose(50 mg·kg-1)for 6 weeks respectirely,and dimethylbiguanide was used as positive control.The pressure,glucose infusion rate(GIR),OGTT,TC,TG,HDL-C,LDL-C were determined after administration.RESULTS The blood glucose of rats in model group was increased and ISI was decreased.Compared with the rats in model group,OGTT in Puerarin high dose group and puerarin low dose group was decreased,GIR was increased(P0.01),blood pressure,TC,TG,LDL-C were decreased and HDL-C was increased(P0.05).CONCLUSION Puerarin can treat MS induced by fructose.