Effects of Fei-te-ling-III on Bleomycin-induced Pulmonary Fibrosis in Mice

Objective To study the effects of Fei-te-ling-Ⅲ on bleomycin(BLM) induced pulmonary fibrosis in mice.Methods The pulmonary fibrosis model was estalished by intratracheal injection of Bleomycin.After 14 d treating mice with Fei-te-ling-Ⅲ by intragastric administration,the lung index,the pathomorphology,and the level of hydroxyproline (HYP ),glutathione (GSH),malondialdehyde (MDA),total antioxidant capacity(T-AOC) in lung tissue and blood serum were measured and analysised.The impact of Fei-te-ling-Ⅲ on pulmonary fibrosis in mice was observed.Results After the treatment of Fei-te-ling-Ⅲ,compared with the model group,pulmonary index and the level of HYP were dramatically decreased (P 0.05 or 0.01).T-AOC in serum was significantly increased,the contents of MDA in serum were significantly decreased,the contents of GSH in lung tissue were significantly increased,Fei-te-ling-Ⅲ could obviously reduced alveolit and pulmonary fibrosis (P 0.05 or 0.01).Conclusion Fei-te-ling-Ⅲ could have therapeutic effects on the early lesions of bleomycin-induced pulmonary fibrosis in mice.The mechanisms may be related to the inhibition of activation of inflammatory cell infiltration,anti-oxidation and the inhibition of collagen to generate.