Research Development of Macrophage Migration Inhibitory Factor in Purpura Nephritis

In recent years,there are more and more researches about macrophage migration inhibitory factor( MIF). The role of MIF involves inflammation,immune,endocrine,tumor,blood vessels and so on.Here is to make an elaboration focusing on the molecular structure,source of MIF,and the molecular and biological mechanism; studies have found that MIF participates in the development of a variety of diseases in the body,especially that MIF-173( G /C) loci single nucleotide polymorphism has a close relationship with the diseases,including Henoch-Schonlein purpura nephritis( HSPN),and MIF C allele may be a susceptibility genes of HSPN. MIF plays an important role in HSPN development,which can be a therapeutic target for the treatment of immune inflammatory disease.