Comparison of cisatracurium and vecuronium in patients undergoing laparoscopic gynecologic surgery

Objective To evaluate and compare the pharmacodynamics differences after single dose of intravenous cisatracurium and vecuronium in the patients undergoing laparoscopic gynecologic surgery.Methods 60 patients of ASA class I or II,undergoing laparoscopy surgery were recruited into this study.They were randomly divided into cisatracurium group(group A,n=30) and vecuronium group(group V,n=30).The TOF-Guard neuromuscular monitor was used to record the response of the adductor pollicis muscle to train-of-four(TOF) stimulations of the ulnar nerve at wrist.Total intravenous anesthesia was induced with midazolam 0.03 mg/kg,fentanyl 3.0 μg/kg and propofol 2.5 mg/kg in both groups.The muscle relaxants was infused at 0.1 mg/kg(2ED95) cisatracurium in group A and 0.1 mg/kg(2ED95) vecuronium in group V saperately before intubation.Anesthesia was maintained with target controlled infusion(TCI)of propofol at an average effect site concentration of 3.0-3.5μg/mL and remifentanil 4.0-5.0ng/mL.Recorded the duration of surgery,tracheal intubating conditions and hemodynamic changes,onset time,nonresponse time,recovery time of T1 to 25%,75%,95%,recovery index,TOFR and side effects.Results There were no significant differences in duration of surgery,tracheal intubating conditions and hemodynamic changes between two groups(P0.05).Following 0.1mg/kg cisatracurium,the onset time was significantly longer compared with groupV(P0.05).In group A recovery of T1 to 25%,75%,95% of control occurred sooner and higher incidence of antagonizing muscle relaxants than group V(P 0.05).There were no significant differences of recovery index and TOFR between the two groups(P0.05).Two groups had no side effects.Conclusion The recovery from single dose of intravenous cisatracurium was more rapidly in laparoscopic gynecologic surgery compared with vecuronium.