Effect of Feixinping on ET and NOSmRNA Expression in Pulmonary Artery in Rats with Pulmonary Hypertension in Pulmonary Heart Disease

Objective:To study the effect of Feixinping on endothelin level in pulmonary artery,NOSmRNA expression in rats with pulmonary hypertension in pulmonary heart disease,and probe in to the action mechanism of Feixinping in treating pulmonary hypertension in pulmonary heart disease.Methods:Rat model of pulmonary hypertension in pulmonary heart disease was duplicated by injection of 2% monocrotaline at dosage of 60mg/Kg peritonially at one time.ET and nitrogen monoxide synthase(NOSmRNA) were determined with RTPCR.Results:Compared to normal group,in model group ETmRNA expression in pulmonary artery increases while NOSmRNA expression decreases;Compared to model group,in Feixingping and Catopril group pulmonary artery ETmRNA expression decrease,increase NOSmRNA expression in pulmonary artery.Conclusion:Feixinping is of good therapeutic effect in treating pulmonary hypertension in pulmonary heart disease.The action of mechanism might be Feixinping can decrease ETmRNA expression in pulmonary artery,increase NOSmRNA expression in pulmonary artery in rats with pulmonary hypertension in pulmonary heart disease.