Disturbance of lymphatic function by Prox1 contributes to mesenteric lesions and the composition of microbiota in Crohn’s disease

Prox1 played the critical role in lymphatic function. Additionally, Prox1-dependent stimulation of lymphatic function could reduce hypertrophy of MAT, modify the composition of microbiota, and ameliorated gut inflammation. Our findings demonstrated that correction of lymphatic function with Prox1 may lead to improved treatments for CD.