Rechallenge of Lamotrigine After Rash

Conclusions: Lamotrigine has been rechallenged safely in select cases; however, it is critical to confirm that the initial rash did not have specific features of a severe rash in order to proceed with safe reintroduction of lamotrigine. This article analyzes the cases in the literature to date and gives recommendations for how to assess whether to rechallenge lamotrigine.