Design, Synthesis, and Antifungal Activities of Novel 1,2,4‐Triazole Schiff Base Derivatives

With the aim to find new compounds with high antifungal activity, 21 4‐amino‐5‐substituted‐1,2,4‐triazole Schiff bases ( 2a – 2g , 3a – 3g , and 4a – 4g ) were designed and synthesized. Their antifungal activities against Pythium solani , Gibberlla nicotiancola , Fusarium oxysporium f. sp. niveum , Gibberlla saubinetii , Alternaria iycopersici , Phytophthora capsici , Physalospora piricola , Cercospora arachidicola hori , and Fusarium oxysporium f. sp. cucumber were tested, parts of the compounds exhibited excellent antifungal activity. This research provides useful information for further study of antifungal agents.