羟醛反应
产量（工程）
化学
羟醛缩合
盐酸盐
制造工艺
硝基
组合化学
有机化学
催化作用
材料科学
复合材料
冶金
烷基
作者
Chinmoy Pramanik,Kiran Bapat,Pradip Patil,Sandeep A. Kotharkar,Yogesh W. More,Dinkar Gotrane,Sudhir P. Chaskar,Ulhas S. Mahajan,Narendra K. Tripathy
标识
DOI：10.1021/acs.oprd.9b00022
摘要
An efficient, short manufacturing process for fenspiride hydrochloride is reported. Nitro-aldol condensation is the key reaction in the developed process. Improved routes to key building blocks are demonstrated by expedient multikilogram production. Hazardous reactions are avoided. API produced following this new route meets the quality requirement NLT 99.70% purity by HPLC with any individual impurity NMT 0.10% with very good yield.
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(2025-6-4)
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