A wide range of bioelectronic devices are commercially available, ranging from biosensors to biomedical implants, with particular interest in improving healthcare condition. This chapter illustrates different aspects of flexible organic bioelectronics. A selection of highlighted seminal work is presented to signify the latest developments in flexible organic bioelectronics. The chapter mainly focuses on the bio-related applications of different types of flexible organic bioelectronics. It gives a brief introduction of organic semiconducting materials used in flexible organic bioelectronics and summarizes the most important flexible organic bioelectronics while considering different types of device platforms, including organic thin-film transistors (OTFTs), organic electrodes, and smart e-textiles. The realization of organic flexible wire electrochemical transistors (WECTs) offers many new possibilities for biological applications using bioelectronic devices integrated with textile materials. Organic bioelectronic device assembled on the flexible substrates provides the flexibility that is essential to improve interaction with biological systems and increase stability and reliability during operations.