In this study two new compounds are prepared 1,3-Oxazolone-5-(4-Cl)-one and Oxazolone-5-(4-NO 2 )-one derivatives by a reaction of glycine with sebacoyl chloride. The two compoundswere identified and characterized by CHN, IR and 1 H-NMR Spectroscopy. Both derivativesshow different biological activity according to the program.