类有机物
平衡
上皮
生物
细胞培养
细胞
细胞生物学
免疫学
免疫系统
遗传学
作者
Yotam E. Bar-Ephraïm,Kai Kretzschmar,Hans Clevers
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2019-12-18
卷期号:20 (5): 279-293
被引量:199
标识
DOI:10.1038/s41577-019-0248-y
摘要
Much of our knowledge regarding the interactions between epithelial tissues and the immune system has been gathered from animal models and co-cultures with cell lines. However, unique features of human cells cannot be modelled in mice, and cell lines are often transformed or genetically immortalized. Organoid technology has emerged as a powerful tool to maintain epithelial cells in a near-native state. In this Review, we discuss how organoids are being used in immunological research to understand the role of epithelial cell–immune cell interactions in tissue development and homeostasis, as well as in diseases such as cancer. Organoid technology has emerged as a powerful tool to maintain epithelial cells in a near-native state that can be used to better understand the interactions between epithelial cells and the immune system in tissue development, homeostasis, infection and cancer.
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