Research advances in Paneth cell and neonatal necrotizing enterocolitis

Paneth cell(PC)can secrete antimicrobial peptides(AMP)such as defensins, which are associated with various intestinal diseases.PC and AMP are able to resist the pathogenic microorganisms, shape the intestinal microflora and protect intestinal stem cells(ISC). Their function is regulated by autophagy, endoplasmic reticulum stress and other factors.Necrotizing enterocolitis(NEC)is one of the most serious and common diseases in the neonatal period, and it is the main cause of premature death due to gastrointestinal diseases.The pathogenesis is not yet clear.Studies have shown that PC is associated with the pathogenesis of NEC.This review summarizes the progress in the relationship between PC and NEC, to provide innovative ideas for NEC pathogenesis. Key words: Paneth cell; Necrotizing enterocolitis; Neonate