氧化磷酸化
化学
神经保护
活性氧
细胞生物学
神经毒性
生物化学
兴奋毒性
抗氧化剂
脂质过氧化
作者
Tommaso Cassano,Lorenzo Pace,Gaurav Bedse,Angelo Michele Lavecchia,Federico De Marco,Silvana Gaetani,Gaetano Serviddio
标识
DOI:10.2174/1567205013666151218132725
摘要
The aetiology of major neurodegenerative diseases such as Alzheimer’s disease (AD) and
Parkinson’s disease (PD) is still unknown, but increasing evidences suggest that glutamate and mitochondria
are two prominent players in the oxidative stress (OS) process that underlie these illnesses.
Although AD and PD have distinct pathological and clinical features, OS is a common mechanism
contributing to neuronal damage. Glutamate is an important neurotransmitter in neurons and glial cells
and is strongly dependent on calcium homeostasis and on mitochondrial function. In the present work we focused on glutamate-
induced calcium signaling and its relation to the mitochondrial dysfunction with cell death processes. In addition,
we have discussed how alterations in this pathway may lead or aggravate the neurodegenerative diseases. Finally, this review
aims to stimulate further studies on this issue and thereby engage a new perspective regarding the design of possible
therapeutic agents or the identification of biomarkers.
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