免疫疗法
癌症研究
肿瘤微环境
免疫系统
背向效应
光敏剂
医学
免疫抑制
免疫原性
胆固醇
癌症免疫疗法
癌症
免疫学
化学
内科学
有机化学
作者
Xinyu Zhang,Zhiru Cao,Chuanhui Song,Wei Zheng,Meng Zhou,Si Chen,Jianchuan Ran,Hongbo Zhang,Zou Huixian,Shengwei Han,Yu Cai,Wei Han
标识
DOI:10.1002/adhm.202300018
摘要
Abstract Impressive results in cancer treatment have been obtained through immunotherapy. However, abnormally high cholesterol metabolism in the tumor microenvironment (TME) leads to poor immunogenicity or even immunosuppression, which dramatically reduces the clinical response of patients with oral squamous cell carcinoma (OSCC) to immunotherapy. In this study, a cholesterol‐modulating nanoplatform (PYT NP) is developed to restore the normal immune microenvironment, significantly inhibiting SQLE (an essential gene for cholesterol biosynthesis in tumor cells) by releasing terbinafine, thereby reducing cholesterol in the TME and suppressing tumor cell proliferation. In addition, the nanoplatform is equipped with a second near‐infrared (NIR‐II) photosensitizer, Y8, which triggers immunogenic cell death of tumor cells, thereby promoting intra‐tumor infiltration and immune activation via the production of damage‐associated molecular patterns for photoimmunotherapy. PYT NPs show great promise in stimulating strong cholesterol‐modulating anticancer immunity combined with photoimmunotherapy, opening up a new avenue for sensitized OSCC immunotherapy.
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