医学
哮喘
粘液
免疫学
炎症
免疫球蛋白E
过敏性炎症
白细胞介素13
胃肠病学
白细胞介素
抗体
细胞因子
生态学
生物
作者
Xing Liu,Entezar Mehrabi Nasab,Seyyed Shamsadin Athari
出处
期刊:Allergologia et immunopathologia
[Codon Publications]
日期:2022-11-01
卷期号:50 (6): 71-75
被引量:1
标识
DOI:10.15586/aei.v50i6.612
摘要
Allergic rhinitis and asthma are the main airway diseases with a higher prevalence. Eosinophilic inflammation, airway hyperresponsiveness, mucus hypersecretion, and reversible airflow obstruction are immunopathogenesis symptoms of rhinitis and asthma. Crotonic acid has bio-activity on the inflammation, and gluconic acid as chelator may protect crotonic acid activity in airway and together may control allergic rhinitis and asthma.Allergic rhinitis and asthma mice models were treated with crotonic and gluconic acids. The total IgE, histamine, IL-4, IL-5, and IL-13 levels were measured. In lung tissues, goblet cell hyperplasia, mucus hypersecretion, and inflammation were evaluated.The level of IL-5, goblet cell hyperplasia, and perivascular and peribronchial inflammation were controlled by crotonic acid in asthma and allergic rhinitis groups. But, total IgE, hista-mine, IL-4, and IL-13 levels, and mucus hypersecretion had no significant changes between treated and nontreated asthma and rhinitis groups.
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