Bipyramidal gold nanoparticles-assisted plasmonic photothermal therapy for ocular applications

analysis was performed by treating pig corneas with BipyAu@citrate NPs (0.18 μg Au) and subsequent NIR laser irradiation at 808 nm for 15 min, showing distortions in the collagen type I fibrils at the ultrastructural level and promoting the flattening of the corneal surface after treatment, without inducing cell cytotoxicity. This work suggests that a precise control of the fibril distortions can be provoked by PPTT mediated with BipyAu@citrate in the NIR region, paving the way for nanomedicine to correct common deficiencies in corneal diseases.