生物
血管生成
病理生理学
炎症
伤口愈合
免疫系统
生物信息学
慢性伤口
免疫学
重症监护医学
医学
病理
癌症研究
作者
Irena Pastar,Nathan C. Balukoff,Jelena Marjanovic,Vivien Y. Chen,Rivka C. Stone,Marjana Tomic‐Canic
出处
期刊:Cold Spring Harbor Perspectives in Biology
[Cold Spring Harbor Laboratory]
日期:2022-09-19
卷期号:15 (4): a041243-a041243
被引量:10
标识
DOI:10.1101/cshperspect.a041243
摘要
Venous leg ulcers, diabetic foot ulcers, and pressure ulcers are complex chronic wounds with multifactorial etiologies that are associated with high patient morbidity and mortality. Despite considerable progress in deciphering the pathologies of chronic wounds using "omics" approaches, considerable gaps in knowledge remain, and current therapies are often not efficacious. We provide a comprehensive overview of current understanding of the molecular mechanisms that impair healing and current knowledge on cell-specific dysregulation including keratinocytes, fibroblasts, immune cells, endothelial cells and their contributions to impaired reepithelialization, inflammation, angiogenesis, and tissue remodeling that characterize chronic wounds. We also provide a rationale for further elucidation of ulcer-specific pathologic processes that can be therapeutically targeted to shift chronic nonhealing to acute healing wounds.
科研通智能强力驱动
Strongly Powered by AbleSci AI