循环肿瘤细胞
螺旋(铁路)
分类
微流控
有限元法
单元格排序
肿瘤细胞
机械
惯性参考系
生物系统
欧拉路径
频道(广播)
材料科学
计算机科学
细胞
物理
拉格朗日
化学
纳米技术
生物
癌症
经典力学
工程类
机械工程
算法
癌症研究
计算机网络
遗传学
转移
热力学
数学物理
生物化学
作者
Roya Mohammadali,Morteza Bayareh
出处
期刊:Micromachines
[MDPI AG]
日期:2023-11-17
卷期号:14 (11): 2111-2111
被引量:1
摘要
The isolation of circulating tumor cells (CTCs) and their analysis are crucial for the preliminary identification of invasive cancer. One of the effective properties that can be utilized to isolate CTCs is their deformability. In this paper, inertial-based spiral microchannels with various numbers of loops are employed to sort deformable CTCs using the finite element method (FEM) and an arbitrary Lagrangian–Eulerian (ALE) approach. The influences of cell deformability, cell size, number of loops, and channel depth on the hydrodynamic behavior of CTCs are discussed. The results demonstrate that the trajectory of cells is affected by the above factors when passing through the spiral channel. This approach can be utilized for sorting and isolating label-free deformable biological cells at large scales in clinical systems.
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