炔丙基
化学
催化作用
炔烃
分子间力
烯丙基重排
烷基化
对映选择合成
过渡金属
有机化学
替代(逻辑)
铜
筑地反应
药物化学
分子
组合化学
计算机科学
程序设计语言
作者
Chunming Gui,Yuanyuan Peng,Yongbo Zhou,Yanfang Zheng,Haifeng Wang,Qiongjiao Yan,Hui Zhou,Wei Wang,Fen‐Er Chen
标识
DOI:10.1021/acscatal.3c03814
摘要
Transition-metal-catalyzed asymmetric allylic alkylation is one of the most powerful and well-known strategies for the construction of C–C bonds; nevertheless, propargylation is elusive and remains far less explored. Here, we report the copper-catalyzed asymmetric propargylic substitution of N-acyl phenylglycine N-hydroxyphthalimide (NHP) esters and racemic propargylic carbonates, which afforded multifunctionalized products bearing a terminal alkyne unit in high yields with good stereoselectivities. Moreover, the product can be readily derivatized into other interesting compounds that have great potential for the exploitation of pharmaceutically relevant molecules.
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