自噬
细胞生物学
细胞质
自噬体
泛素
化学
生物
生物化学
细胞凋亡
基因
作者
Yatao Chen,Yuzhi Wang,Xiaoying Pei,Tan Wang,Jun Zhang,Yan Liu
标识
DOI:10.1016/j.bbrc.2023.10.033
摘要
Tripartite motif (TRIM) family proteins as E3-ligases participate in various biological processes. TRIM21, as the first autoantibody protein, has been found to be associated with autophagy. However, the role of TRIM21 engaging in autophagy is still unclear. In this study, TRIM21 forms significate puncta in the cytoplasm and undergoes liquid-liquid phase separation in vitro. Furthermore, we identify phase separation of the coiled-coil (CC) domain is essential for autophagosome to mediate autophagy-related protein recruited. These findings show that phase separation of the CC domain of TRIM21 promotes autophagosome to impact cell fate.
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