肠神经系统
自闭症谱系障碍
自闭症
胃肠道
失调家庭
肠-脑轴
神经发育障碍
功能性胃肠病
医学
神经科学
胃肠道疾病
神经系统
生物信息学
肠道菌群
肠易激综合征
心理学
生物
精神科
免疫学
内科学
作者
Xin‐Nian Wang,Ruimin Tang,Zhen Wei,Yang Zhan,Jianping Lu,Zhiling Li
标识
DOI:10.3389/fnins.2023.1101071
摘要
Gastrointestinal (GI) disorders are common comorbidities in individuals with autism spectrum disorder (ASD), and abnormalities in these issues have been found to be closely related to the severity of core behavioral deficits in autism. The enteric nervous system (ENS) plays a crucial role in regulating various aspects of gut functions, including gastrointestinal motility. Dysfunctional wiring in the ENS not only results in various gastrointestinal issues, but also correlates with an increasing number of central nervous system (CNS) disorders, such as ASD. However, it remains unclear whether the gastrointestinal dysfunctions are a consequence of ASD or if they directly contribute to its pathogenesis. This review focuses on the deficits in the ENS associated with ASD, and highlights several high-risk genes for ASD, which are expressed widely in the gut and implicated in gastrointestinal dysfunction among both animal models and human patients with ASD. Furthermore, we provide a brief overview of environmental factors associated with gastrointestinal tract in individuals with autism. This could offer fresh perspectives on our understanding of ASD.
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