发酵
生化工程
工艺工程
生产(经济)
生物反应器
分离(统计)
按需
产量(工程)
下游加工
化学
制浆造纸工业
计算机科学
色谱法
工程类
材料科学
食品科学
多媒体
有机化学
机器学习
冶金
经济
宏观经济学
作者
Feng Xu,Chen Yang,Xiang Zou,Ju Chu,Xiaohui Tian
标识
DOI:10.1016/j.biortech.2023.129719
摘要
Sophorolipids (SLs) represent highly promising biosurfactants. However, its widespread production and application encounter obstacles due to the significant costs involved. Here, an intelligent and precise regulation strategy was elucidated for the fermentation process coupled with in-situ separation production mode, to achieve cost-effective SLs production. Firstly, a mechanism-assisted data-driven model was constructed for "on-demand feeding of cells". Moreover, a strategy of step-wise oxygen supply regulation based on the demand for cell metabolic capacity was developed, which accomplished "on-demand oxygen supply of cells", to optimize the control of energy consumption. Finally, a systematic approach was implemented by integrating a semi-continuous fermentation mode with in-situ separation technology for SLs production. This strategy enhanced SLs productivity and yield, reaching 2.30 g/L/h and 0.57 g/g, respectively. These values represented a 40.2% and 18.7% increase compared to fed-batch fermentation. Moreover, the concentration of crude SLs after separation reached 793.12 g/L, facilitating downstream separation and purification processes.
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