去氢骆驼蓬碱
核酸
去氢骆驼蓬碱
小分子
体外
生物化学
行动方式
化学
生物碱
细胞毒性
计算生物学
生物
药理学
立体化学
作者
Paromita Bhattacharjee,Pranab Sarkar,Kakali Bhadra
标识
DOI:10.1080/10286020.2023.2251116
摘要
Use of small molecules as valuable drugs against diseases is still an indefinable purpose due to the lack of in-detail knowledge regarding proper bio-target identification, specificity aspects, mode-mechanism of binding and proper in vitro study. Harmaline, an important beta-carboline alkaloid, shows effective anti-proliferative action against different types of human cancers and is also found to be a nucleic acid targeting natural molecule. This review sought to address the different signal pathways of apoptosis by harmaline in different cancer cell lines and simultaneously to characterize the structure activity aspects of the alkaloid with different motifs of nucleic acid to show its preference, biological efficacy and genotoxicity. The results open up new insights for the design and development of small molecule-based nucleic acid therapeutic agents.
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