蝎子
钠通道
毒液
蝎子毒素
毒素
药理学
蝎子毒
离子通道
导航1
化学
生物
医学
钠
生物化学
受体
有机化学
作者
Minzhi Chen,Minjuan Lu,Xujun Feng,Mengyin Wu,Xiao‐Dong Luo,Rong Xiang,Ren C. Luo,Huayue Wu,Liu Z,Meichi Wang,Xi Zhou
出处
期刊:Toxicon
[Elsevier]
日期:2023-12-01
卷期号:236: 107331-107331
标识
DOI:10.1016/j.toxicon.2023.107331
摘要
Polypeptide toxins are major bioactive components found in venomous animals. Many polypeptide toxins can specifically act on targets, such as ion channels and voltage-gated sodium (Nav) channels, in the nervous, muscle, and cardiovascular systems of the recipient to increase defense and predation efficiency. In this study, a novel polypeptide toxin, LmNaTx15, was isolated from the venom of the scorpion Lychas mucronatus, and its activity was analyzed. LmNaTx15 slowed the fast inactivation of Nav1.2, Nav1.3, Nav1.4, Nav1.5, and Nav1.7 and inhibited the peak current of Nav1.5, but it did not affect Nav1.8. In addition, LmNaTx15 altered the voltage-dependent activation and inactivation of these Nav channel subtypes. Furthermore, like site 3 neurotoxins, LmNaTx15 induced pain in mice. These results show a novel scorpion toxin with a modulatory effect on specific Nav channel subtypes and pain induction in mice. Therefore, LmNaTx15 may be a key bioactive component for scorpion defense and predation. Besides, this study provides a basis for analyzing structure-function relationships of the scorpion toxins affecting Nav channel activity.
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