A randomized, double‐blind, placebo‐controlled study of Cistanche tubulosa and Ginkgo biloba extracts for the improvement of cognitive function in middle‐aged and elderly people

Abstract Mild cognitive impairment poses an increasing challenge to middle‐aged and elderly populations. Traditional Chinese medicinal herbs like Cistanche tubulosa and Ginkgo biloba (CG) have been proposed as potential agents to improve cognitive and memory functions. A randomized controlled trial involving 100 Chinese middle‐aged and elderly participants was conducted to investigate the potential synergistic effects of CG on cognitive function in individuals at risk of neurodegenerative diseases. Over 90 days, both CG group and placebo group received two tablets daily, with each pair of CG tablets containing 72 mg echinacoside and 27 mg flavonol glycosides. Cognitive functions were assessed using multiple scales and blood biomarkers were determined at baseline, Day 45, and Day 90. The CG group exhibited significant improvements in the scores of Mini‐Mental State Examination (26.5 at baseline vs. 27.1 at Day 90, p < 0.001), Montreal Cognitive Assessment (23.4 at baseline vs. 25.3 at Day 90, p < 0.001), and World Health Organization Quality of Life (81.6 at baseline vs. 84.2 at Day 90, p < 0.001), all surpassing scores in placebo group. Notably, both the Cognitrax matrix test and the Wechsler Memory Scale‐Revised demonstrated enhanced memory functions, including long‐term and delayed memory, after CG intervention. Moreover, cognitive‐related blood biomarkers, including total tau, pT181, pS199, pT231, pS396, and thyroid‐stimulating hormone, significantly decreased, whereas triiodothyronine and free triiodothyronine significantly increased. No treatment‐related adverse events were reported, and routine blood and urine tests remained stable. These findings indicated that CG supplementation could potentially serve as an effective supplementary solution for enhancing cognitive and memory functions.