衰老
癌症
细胞衰老
重编程
细胞代谢
细胞代谢
病态的
机制(生物学)
癌细胞
生物信息学
生物
医学
新陈代谢
癌症研究
神经科学
细胞
内科学
细胞生物学
遗传学
内分泌学
基因
表型
哲学
认识论
作者
Yeonju Kim,Yeji Jang,Mi-Sung Kim,Chanhee Kang
标识
DOI:10.1016/j.tem.2024.02.008
摘要
Cellular metabolism is a flexible and plastic network that often dictates physiological and pathological states of the cell, including differentiation, cancer, and aging. Recent advances in cancer metabolism represent a tremendous opportunity to treat cancer by targeting its altered metabolism. Interestingly, despite their stable growth arrest, senescent cells - a critical component of the aging process - undergo metabolic changes similar to cancer metabolism. A deeper understanding of the similarities and differences between these disparate pathological conditions will help identify which metabolic reprogramming is most relevant to the therapeutic liabilities of senescence. Here, we compare and contrast cancer and senescence metabolism and discuss how metabolic therapies can be established as a new modality of senotherapy for healthy aging.
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