疾病
破译
医学
重症监护医学
无麸质
透视图(图形)
集合(抽象数据类型)
面筋
生物信息学
病理
计算机科学
人工智能
生物
程序设计语言
作者
Robert P. Anderson,R Verma,Michael Schümann
标识
DOI:10.1053/j.gastro.2024.02.005
摘要
Abstract
As it appears that we are currently at the cusp of an era in which drugs that are new, re-purposed or as "supplements", will be introduced to the management of celiac disease, we need to reflect if the framework is set for celiac disease to be increasingly treated by pharmaceuticals as well as diet. This refers to reflecting on the rigor of current diagnostic practices, the limitations of the current standard of care that is gluten-free diet, and that we lack objective markers of disease severity. Interrogating these issues will help us to identify gaps in technology and practices that could be critical for selecting patients with a well-defined need for an improved or alternative treatment. Both aspects, circumscribed limitations of the gluten-free diet and diagnostics helping to define celiac disease target groups, together with the guiding requirements by the responsible regulatory authorities will contribute to defining the subgroups of patients with confirmed celiac disease eligible for distinct pharmacological strategies. Because many celiac disease patients are diagnosed in childhood, these aspects need to be differentially discussed for the pediatric setting. In this perspective, we aim to describe these contextual issues and then look ahead to the future. What might be the major challenges in celiac disease clinics in the coming years once drugs are an option alongside the diet? And what will be future objectives for researchers who further decipher the mucosal immunology of celiac disease? Speculating on the answers to these questions is as stimulating as it is fascinating to be part of this turning point.
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