吡喃酮
肺炎克雷伯菌
立体化学
抗菌活性
圆二色性
金黄色葡萄球菌
二维核磁共振波谱
真菌
化学
生物
微生物学
植物
细菌
大肠杆菌
生物化学
基因
遗传学
作者
Hong Pu,Dian Peng,Genyun Tang,Qiang Ma,Huaiyi Huang,Ya-Ni Zhong,Jiayao Long,Xueshuang Huang,Yanwen Duan,Yong Huang
标识
DOI:10.1080/14786419.2023.2204434
摘要
An undescribed α-pyrone diaporpyrone E (1), and three known nucleotides, 5’-O-acetyl uridine (2), 5’-O-acetyl thymidine (3), and adenine (4), were identified from Diaporthe sp. CB10100, an endophytic fungus isolated from the medicinal plant Sinomenium acutum. The structure of 1 was determined by extensive analysis of its HRMS, 1D and 2D NMR spectroscopic data, as well as electronic circular dichroism calculations and comparison. The in vitro cytotoxic and antibacterial assays of 1 revealed that it has a 30.2% inhibitory effect on HepG2 cells at 50 μM, while no antibacterial activities against Staphylococcus aureus and Klebsiella pneumoniae at 64 μg/mL.
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