Interplay of epigenetic regulation and chromatin-lamina interaction modulates the morphology of lamina-associated domains

In eukaryotic nuclei, a significant portion of transcriptionally repressed chromatin is anchored to the nuclear lamina (NL), leading to the formation of lamina-associated domains (LADs). LADs are marked by increased histone methylation levels and are physically or chemically tethered to NL via proteins such as lamina-associated polypeptide 2β (LAP2β). The spatial organization of LADs exerts stimulating effects on gene repression and cell function. Here, we propose a phase-field model of chromatin organization to address the mechanisms underlying the morphological regulation of LADs.