纳米探针
膀胱癌
医学
荧光
灌注
放射科
核医学
生物医学工程
泌尿科
癌症
化学
内科学
光学
物理
作者
Shilei Ren,Rong Dai,Ziliang Zheng,Qin Liu,Xiaochun Zheng,Juan Li,Shutong Wu,Ruiping Zhang,Zhiguo Gui
标识
DOI:10.1016/j.nano.2023.102661
摘要
Intravesical instillation has been considered an efficient route for detecting bladder cancer. However, only a small fraction of administered dose permeates into tumor tissues, and insufficient retention time limits their application. In this work, a novel intravesical bidirectional perfusion-like administered mode was developed to improve diagnostic accuracy of bladder tumor imaging. Specifically, the ultrasmall AuPd-P-FA Nanoprobe exhibit excellent NIR-II FL imaging performance due to electronic structure perturbation. Benefiting from the size advantage for kidney metabolism and FA targeting specificity, AuPd-P-FA could effectively administration to bladder tumor. When AuPd-P-FA reached maximum enrichment at 1 h post-injection, the localized and mild thermal energy produced upon laser irradiation activated a phase transition. This thermo-sensitive characteristic could prolong the retention time in bladder and the fluorescence signal could be clearly observed at 6 h post-injection with high accuracy. This novel intravesical bidirectional perfusion-like administered mode is expected to achieve a non-invasive diagnosis of early bladder cancer.
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