Early-stage mycosis fungoides: searching for biomarkers associated with advanced-stage progression

This study shows that the microenvironment and probably the phenotype of neoplastic T cells of early-stage mycosis fungoides (MF) samples from patients with MF who suffered progression or remained stable are different. Moreover, we propose that the overexpression of CD30, CXCL13 and BIRC3 in early-stage MF is related to progression. Further spatial transcriptomic studies or single-cell analysis in further case series are needed to corroborate our findings.