THE ROLE OF SYSTEMIC INFLAMMATION IN THE PATHOGENESIS OF METABOLIC DISORDERS. PART I. CONCEPT OF SYSTEMIC INFLAMMATION AND ITS PATHOGENESIS

Gozhenko A. I., Hryshko Yu. M., Gramatiuk S. M. THE ROLE OF SYSTEMIC INFLAMMATION IN THE PATHOGENESIS OF METABOLIC DISORDERS. PART I. CONCEPT OF SYSTEMIC INFLAMMATION AND ITS PATHOGENESIS. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2019;3(84):91-100. ISSN 0049-6804. DOI http://dx.doi.org/10.5281/zenodo.3465995 http://www.herald.com.ua УДК 616-002:616-098 DOI http://dx.doi.org/10.5281/zenodo.3465995 THE ROLE OF SYSTEMIC INFLAMMATION IN THE PATHOGENESIS OF METABOLIC DISORDERS. PART I. CONCEPT OF SYSTEMIC INFLAMMATION AND ITS PATHOGENESIS Gozhenko A. I., Hryshko Yu. M., Gramatiuk S. M. Ukrainian Research Institute for Medicine of Transport of Ukrainian Ministry of Health Care, Odessa; Ukrainian Medical Stomatological Academy, Poltava; Limited Liability Company Institute of Cell Biorehabilitation, Kharkіv e-mail: hryshko@ukr.net. Summary. In recent years, the concept of systemic inflammation has emerged - as a typical, pathological process. The development of systemic inflammation as a form of response to systemic alteration is accompanied by functional activation of cells of the lymphoreticular system, which is ensured by changes in metabolism, which further causes the development of insulin resistance, type 2 diabetes mellitus (CD2), atherosclerosis resulting from impaired functional-metabolic continuum (FMC), the concept of which has been formulated in recent years, which indicates the relatively constant nature of metabolism and its parameters in the intercellular environment. Thus, in its turn, is closely connected to the functional activity of organs and cells, thus forming a single system – the continuum. It has been shown that along with the well-known systemic manifestations observed in classical inflammation, as a predominantly local process, there are phenomena inherent in the body that are inflammatory but not local but systemic. Further studies should identify systemic inflammation as a distinct typical pathological process. Key words: systemic inflammation, metabolism, diabetes mellitus, cytokines, insulin resistance.