生物膜
生物
斑马鱼
黑腹果蝇
动物模型
致病性
模式生物
微生物学
秀丽隐杆线虫
计算生物学
细菌
遗传学
基因
内分泌学
作者
Huan Xu,Jing Liu,Zhaohuan Zhang,Qian Tao,Zhenhua Huang,Yingjie Pan,Yong Zhao
出处
期刊:PubMed
日期:2022-08-25
卷期号:38 (8): 2840-2856
标识
DOI:10.13345/j.cjb.220143
摘要
Biofilm formation is closely related to pathogenicity and antibiotic resistance of bacteria, and plays important roles in a number of chronic and subchronic infections. Animal models are widely used in the research of bacterial biofilm-associated infections, and provide a powerful scientific tool for investigating its pathogenesis and control strategies. This review summarized the application of mammalian models (e.g. mouse, rabbit, and pig) and non-mammalian models (e.g. Drosophila melanogaster, Zebrafish, and Caenorhabditis elegans) in bacterial biofilm studies, and prospects the application of animal models in biofilm. This review may facilitate the selection of suitable animal models in the study of biofilm-associated infections, so as to prevent and control the potential adverse effects.
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