Resveratrol enhances duck cathelicidin expression in heterophilic granulocytes via MAPK–EGR1 signalling pathway

1. This study investigated whether resveratrol (RES) can regulate the expression of duck cathelicidins (dCATHs) in heterophilic granulocytes (HGs). To address this, HG was isolated from ducks and treated with RES, followed by transcriptome sequencing to explore potential regulatory pathways.2. Ducks receiving RES treatment had significantly increased dCATH expression in HG. Transcriptomic analysis suggested that this was associated with anti-inflammatory responses and activation of the mitogen-activated protein kinase (MAPK) signalling pathway.3. The results indicated that RES upregulates dCATH expression, potentially through MAPK pathway activation, which would contribute to enhanced immune function in ducks.