Transcriptomic and epigenetic mechanisms controlling cholangiocytes transdifferentiation into hepatocytes

Overall, our results confirm that cholangiocytes can transdifferentiate into hepatocytes. This process is promoted by HNF4G, it involves epigenetic remodelling, and is consistent across the three liver lobes. This knowledge paves the way for future therapies aiming to enhance liver regeneration by increasing cholangiocytes' plasticity.