病理
腺样囊性癌
外阴
肌上皮细胞
癌
唾液腺
生物
乳腺
医学
癌症
乳腺癌
免疫组织化学
遗传学
作者
Charlotte C. Currie,Darren Leaning,W. Glenn McCluggage,Emma Spoor
标识
DOI:10.1097/pgp.0000000000001034
摘要
Human papillomavirus (HPV)–associated multiphenotypic sinonasal carcinoma is a rare and recently described epithelial neoplasm exhibiting myoepithelial differentiation and morphological overlap with salivary gland neoplasms, especially adenoid cystic carcinoma; it is commonly associated with HPV, especially type 33. It has mainly been reported in the nasal cavity and paranasal sinuses with a single case reported in the breast. Herein, we report the first vulval example in a 47-year-old patient who presented with a large craggy mass in the region of the Bartholin gland. The histologic features were of a high-grade carcinoma composed of basaloid cells arranged in sheets and nests, with occasional ductal formations, surrounded by densely hyalinised basement membrane-type material. There was diffuse block-type immunoreactivity with p16 and HPV genotyping revealed high-risk HPV type 16. In reporting this case, we highlight the propensity for “salivary gland-type” neoplasms to arise in the vulva, especially in the Bartholin gland, and stress that pathologists should consider salivary-type neoplasms when faced with a morphologically unusual vulval tumor.
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