双氢青蒿素
前药
硫醚
紫杉醇
细胞内
程序性细胞死亡
癌症
癌细胞
化学
药理学
活性氧
癌症研究
细胞凋亡
化疗
生物化学
立体化学
生物
免疫学
恶性疟原虫
青蒿素
疟疾
遗传学
作者
Yifei Zheng,Chao Qin,Fei Li,Jingxin Qi,Xinyu Chu,Hao Li,Ting Shi,Zhen Yan,Lei Yang,Xiaofei Xin,Lisha Liu,Xiaopeng Han,Lifang Yin
摘要
In this study, ROS-sensitive prodrug nanoassemblies composed of a single thioether bond bridged dihydroartemisinin-paclitaxel prodrug was constructed. The nanoassemblies with enhanced ferroptotic-chemotherapy promoted tumor cell death.
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