Cobalt-Catalyzed Enantioselective Hydroarylation of 1,6-Enynes

An asymmetric hydroarylative cyclization of enynes involving a C–H bond cleavage is reported. The cobalt-catalyzed cascade generates three new bonds in an atom-economical fashion. The products were obtained in excellent yields and excellent enantioselectivities as single diastereo- and regioisomers. Preliminary mechanistic studies indicate that the reaction shows no intermolecular C–H crossover. This work highlights the potential of cobalt catalysis in C–H bond functionalization and enantioselective domino reactivity.