神经炎症
神经退行性变
干扰素基因刺激剂
免疫系统
神经科学
先天免疫系统
信号转导
神经保护
炎症
干扰素
细胞生物学
刺
生物
免疫学
疾病
医学
内科学
工程类
航空航天工程
作者
Bindu D. Paul,Solomon H. Snyder,Vilhelm A. Bohr
标识
DOI:10.1016/j.tins.2020.10.008
摘要
Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is relayed via the cGAS-STING pathway: this involves the activation of cyclic GMP-AMP (cGMP-AMP) synthase (cGAS) and generation of the cyclic dinucleotide cGAMP, followed by the induction of stimulator of interferon genes (STING). The cGAS-STING pathway responds to viral, bacterial, and self-DNA. Whereas it generally mediates immune surveillance and is often neuroprotective, excessive engagement of the system can be deleterious. This is relevant in aging and age-related neurological diseases, where neuroinflammation contributes to disease progression. This review focuses on cGAS-STING signaling in aging, neurodegeneration, and neuroinflammation, and on therapeutic implications.
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