生物
纤毛
节的
脊椎动物
细胞生物学
不对称
侧板中胚层
中胚层
运动纤毛
解剖
谱系(遗传)
皮特x2
基因
遗传学
基因表达
胚胎干细胞
同源盒
物理
量子力学
作者
Rosie B Little,Dominic P. Norris
标识
DOI:10.1016/j.semcdb.2020.06.003
摘要
The initial breaking of left-right (L-R) symmetry in the embryo is controlled by a motile-cilia-driven leftward fluid flow in the left-right organiser (LRO), resulting in L-R asymmetric gene expression flanking the LRO. Ultimately this results in left- but not right-sided activation of the Nodal-Pitx2 pathway in more lateral tissues. While aspects of the initial breaking event clearly vary between vertebrates, events in the Lateral Plate Mesoderm (LPM) are conserved through the vertebrate lineage. Evidence from model systems and humans highlights the role of cilia both in the initial symmetry breaking and in the ability of more lateral tissues to exhibit asymmetric gene expression. In this review we concentrate on the process of L-R determination in mouse and humans.
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