Prognostic Significance of the Hsp70 Gene Family in Colorectal Cancer

BACKGROUND Colorectal cancer (CRC) is a deadly form of cancer worldwide. Heat shock protein 70 (Hsp70) belongs to the family of human HSPs and plays an essential role in multiple cellular developments and in responding to environmental changes. However, studies on the relationship between CRC and the Hsp70 family are rare. MATERIAL AND METHODS Data pertaining to 438 patients with CRC was downloaded from The Cancer Genome Atlas database. To investigate the prognostic significance of the Hsp70 genes, survival and joint-effect analyses were conducted. The correlation between prognosis-related Hsp70 genes and clinical factors in CRC was analyzed using a nomogram. Gene set enrichment analysis (GSEA) was performed to explore the complex enrichment pathway in CRC with the prognosis-related Hsp70 genes. RESULTS According to multivariate Cox regression survival analysis, low expression levels of HSPA1A, HSPA1B, and HSPA1L were correlated with improved overall survival (OS). According to the joint-effects survival analysis, the joint low expression levels of HSPA1A, HSPA1B, and HSPA1L were related to improved OS. The 1-, 3-, 5-, and 10-year survival rates of patients with CRC were predicted by constructing a nomogram model based on HSPA1A, HSPA1B, HSPA1L, and tumor stage. The GSEA results indicated the biological roles of HSPA1A, HSPA1B, and HSPA1L in CRC. CONCLUSIONS Low expression levels of HSPA1A, HSPA1B, and HSPA1L were strongly correlated with improved prognosis in CRC and might serve as latent prognostic biomarkers in CRC.