生物相容性
发光
荧光
激发波长
材料科学
共轭体系
聚合物
纳米技术
激发
光电子学
波长
光学
复合材料
工程类
冶金
物理
电气工程
作者
Wing‐Fu Lai,Eric M. Huang,Wing Tak Wong
标识
DOI:10.1016/j.apmt.2020.100876
摘要
Sustained-release carriers with intrinsic luminescence exhibit the potential to combine imaging with bioactive agent delivery in practice. This study reports the synthesis and properties of CT, which is a gel-forming and highly tunable non-conjugated polymer with intrinsic luminescence. Owing to the excitation wavelength-dependent emission tunability of CT, optical imaging can be performed in a wide range of excitation wavelengths. This study is the first proof-of-concept study successfully integrating the property of clusterization-triggered emission into carrier design for combining imaging with bioactive agent delivery. By using cancer therapy as a practical example, our results demonstrate that CT is a depot system that cannot only enhance in vivo antitumor efficacy but can also allow its location and gelation process to be tracked in real time by giving an intrinsic blue-colored fluorescence signal. Together with its high biocompatibility, CT shows high practical potential for executing self-illuminating therapy to tackle cancer.
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